Specify the 'Configure removal of items from Quarantine folder' (PurgeItemsAfterDelay in days Min:0 Max:10000000) This policy setting defines the number of days items should be kept in the Quarantine folder before being removed. If you enable this setting, items will be removed from the Quarantine folder after the number of days specified. If you disable or do not configure this setting, items will be kept in the quarantine folder indefinitely and will not be automatically removed. Counter Measure: Configure this setting depending on your organization's requirements. Potential Impact: If enabled, this setting could prevent users from accessing an infected file that contains irreplaceable data. If disabled or not configured, items will be kept in the quarantine folder indefinitely and will not be automatically removed, which will consume disk space.

[max number of days]

(1) GPO: Computer ConfigurationAdministrative TemplatesWindows ComponentsWindows DefenderQuarantineConfigure removal of items from Quarantine folder (2) REG: HKEY_LOCAL_MACHINESoftwarePoliciesMicrosoftWindows DefenderQuarantinePurgeItemsAfterDelay